GABAA-α5 Program
Cognitive Impairment
Key Facts
About Newleos
Newleos is a private, clinical-stage biotech leveraging a pipeline of oral small molecules with first- or best-in-class potential in large neuropsychiatric indications. The company's assets, licensed from Roche, target novel mechanisms including GABAA-γ1, V1a, TAAR1, and GABAA-α5, aiming to improve upon the efficacy and safety profiles of current standards of care like SSRIs and benzodiazepines. Its lead program, NTX-1955, is a selective GABAA-γ1 PAM in Phase 1b studies for generalized anxiety disorder, designed to provide anxiolytic efficacy without the sedative and cognitive side effects associated with non-selective benzodiazepines. Newleos represents a specialized player in the high-unmet-need CNS space, backed by experienced leadership and venture capital.
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