ClpP Activator Platform

About Arietis Pharma

Arietis Pharma is a private, preclinical-stage biotech developing a novel class of antibiotics that activate the ClpP protease, causing bacterial cells to self-digest. This unique mechanism offers rapid killing of drug-resistant Gram-positive pathogens, including MRSA and VRE, and is effective against non-growing cells and biofilms where traditional antibiotics fail. Founded on technology from Northeastern University's Antimicrobial Discovery Center, the company aims to treat complicated infections like prosthetic joint infections and endocarditis. Its strategy includes combining ClpP activators with traditional antibiotics to prevent resistance and eradicate persistent infections.

Therapeutic Areas