AT-02
Mutant CALR-driven Myeloproliferative Neoplasms (MPNs)
Pre-clinicalActive
Key Facts
Indication
Mutant CALR-driven Myeloproliferative Neoplasms (MPNs)
Phase
Pre-clinical
Status
Active
Company
About Alethio Therapeutics
Alethio Therapeutics is a private, preclinical-stage biotech spin-out from the University of Oxford, founded in 2019 and based in Cambridge, UK. The company is focused on developing first-in-class, disease-modifying therapies for myeloproliferative neoplasms (MPNs), a group of incurable chronic blood cancers. Its pipeline is driven by the ARTEMIS platform, which integrates a vast repository of patient-derived data, advanced 'omics, and organoid models to identify and de-risk novel targets. Alethio emerged from stealth in late 2025 with two ADC programs and appointed a new CEO and Chair to advance its lead candidate towards clinical studies.
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