Yecuris

Yecuris is a specialized preclinical contract research organization (CRO) and model provider founded in 2007 and based in Portland, Oregon. The company has developed and commercialized a proprietary, patented platform of FRG® KO liver-humanized mice, which are immunodeficient mice engrafted with functional human liver cells, enabling the study of human-specific liver biology, disease, and drug responses in vivo. Yecuris leverages this platform to offer both ready-to-use animal models and full-service, collaborative research studies, primarily targeting clients in gene and cell therapy, infectious disease (like hepatitis), and metabolic disease (such as NASH/NAFLD) research. Its value proposition centers on providing 'human-relevant' data earlier in the drug discovery cycle, saving clients time and resources.

FRG® KO platform: A triple-knockout (Fah -/- Rag2 -/- Il2rg -/-) mouse strain that enables high-level, stable engraftment of functional human hepatocytes, creating liver-humanized mice for preclinical research.

Yecuris competes in the humanized mouse model segment against large animal model providers like The Jackson Laboratory and Taconic Biosciences, as well as other CROs. Its key differentiation is its deep specialization and validated expertise in liver humanization using the patented FRG® KO platform, as opposed to more generalized humanized immune system models.