Xeris Pharmaceuticals

Xeris Pharmaceuticals

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Private Company

Total funding raised: $200M

Market Cap: $1.0BPipeline: 19 drugs (4 Phase 3)Patents: 20Founded: 2005Employees: 200-500HQ: Chicago, United States

Overview

Xeris Pharmaceuticals' mission is to develop and commercialize novel, ready-to-use injectable drug formulations that overcome stability and delivery challenges. The company has successfully leveraged its proprietary technology platforms to bring multiple products to market, including Gvoke® for severe hypoglycemia and Keveyis® for primary periodic paralysis. Its strategy focuses on expanding its commercial portfolio, advancing a deep pipeline of 19+ candidates, and forming strategic partnerships to apply its formulation expertise to a broad range of therapeutics. Xeris operates as an integrated biopharma company, controlling development, manufacturing, and commercialization.

EndocrinologyNeurologyMetabolic

Technology Platform

Xeris's proprietary XeriSol™ and XeriJect™ platforms enable the development of ready-to-use, room-temperature stable liquid and suspension formulations of peptides, proteins, and small molecules, eliminating the need for reconstitution or refrigeration.

Pipeline

19
19 drugs in pipeline4 in Phase 3
DrugIndicationStageWatch
G-Pen (glucagon injection) + Lilly Glucagon (glucagon inject...HypoglycemiaPhase 3
G-Pen + Novo GlucagonInsulin HypoglycemiaPhase 3
G-Pen + Lilly GlucagonInsulin HypoglycemiaPhase 3
GlucagonDiabetes Mellitus, Type 1Phase 3
Glucagon RTUHyperinsulinemic HypoglycemiaPhase 2

Funding History

5
Total raised:$200M
PIPE$50M
IPO$75M
Series C$45M
Series B$20M

FDA Approved Drugs

7
RECORLEVNDADec 30, 2021
GVOKE KITNDASep 10, 2019
GVOKE PFSNDASep 10, 2019

Opportunities

Significant growth potential lies in expanding the label and market share for Gvoke® in diabetes, advancing a next-generation glucagon analog (XP-8121) into the large obesity market, and leveraging its validated platforms through new high-value partnerships with large pharmaceutical companies seeking formulation solutions for their pipelines.

Risk Factors

Key risks include commercial execution challenges against competing products, clinical trial failures in the pipeline, potential future dilution from capital raises, and dependency on a limited number of marketed products for near-term revenue growth.

Competitive Landscape

Xeris faces product-level competition from other glucagon therapies and rare disease treatments. At the platform level, it competes with other drug delivery technology firms, but differentiates itself through its proven, specialized expertise in ready-to-use, stable liquid formulations of complex molecules.

Company Timeline

2005Founded

Founded in Chicago, United States

2016Series C

Series C: $45.0M

2018IPO

IPO — $75.0M

2019FDA Approval

FDA Approval: GVOKE KIT

2019FDA Approval

FDA Approval: GVOKE PFS

2020PIPE

PIPE: $50.0M