Xencor

Xencor

XNCRPhase 2
Pasadena, United Statesxencor.com

Xencor is a publicly traded biotechnology company focused on redesigning antibody drugs from the ground up using its core XmAb Fc domain engineering platform. The company has established a robust pipeline of over 20 clinical-stage programs and has successfully partnered its technology, resulting in three marketed drugs. Xencor's strategy combines proprietary drug development in oncology and autoimmunity with a prolific licensing model that extends its technology to major pharmaceutical partners.

Market Cap
$889.6M
Focus
AntibodiesBiologics

XNCR · Stock Price

USD 12.1316.00 (-56.88%)

Historical price data

AI Company Overview

Xencor is a publicly traded biotechnology company focused on redesigning antibody drugs from the ground up using its core XmAb Fc domain engineering platform. The company has established a robust pipeline of over 20 clinical-stage programs and has successfully partnered its technology, resulting in three marketed drugs. Xencor's strategy combines proprietary drug development in oncology and autoimmunity with a prolific licensing model that extends its technology to major pharmaceutical partners.

Technology Platform

XmAb® protein engineering platform that uses rational design to modify antibody Fc domains, enabling enhanced functions like extended half-life, increased cytotoxicity, and stable bispecific antibody structures in a 'plug-and-play' format.

Pipeline Snapshot

25

25 drugs in pipeline

DrugIndicationStage
XmAb23104SarcomaPhase 2
XmAb20717Biliary Tract CancerPhase 2
Plamotamab + Tafasitamab + LenalidomideDiffuse Large-cell B-cell LymphomaPhase 2
XmAb5871IgG4-RDPhase 2
vudalimab monotherapyMetastatic Castration-Resistant Prostate CancerPhase 2

Funding History

4

Total raised: $82M

IPO$45MUndisclosedNov 7, 2013
Series B$25MMPM CapitalJun 15, 2001
Series A$10MDomain AssociatesJun 15, 1999
Seed$2MUndisclosedJun 15, 1997

Opportunities

Significant growth opportunities lie in the advancement of its proprietary bispecific antibody pipeline in oncology and the expansion of its autoimmune portfolio.
Furthermore, the company's platform licensing model provides a scalable, low-capital-intensity revenue stream as more partners advance XmAb-based drugs through development and to market.

Risk Factors

Key risks include clinical trial failures for lead proprietary assets, intense competition in core therapeutic areas, dependence on partners for a portion of revenue, and the need to protect its core intellectual property.
The company also faces financing risks inherent in clinical-stage biotech.

Competitive Landscape

Xencor competes with large biopharma and specialized biotechs in antibody engineering (e.g., Regeneron, Adimab) and bispecific development (e.g., Amgen, Roche). Its differentiation stems from its modular, Fc-focused 'plug-and-play' platform, which offers partners and internal programs a streamlined path to improved antibody performance and novel bispecific formats.

Publications
18
Patents
20
Pipeline
25

Company Info

TypeTherapeutics
LocationPasadena, United States
StagePhase 2
RevenueRevenue Generating

Trading

TickerXNCR
ExchangeNASDAQ

Contact

Therapeutic Areas

OncologyAutoimmune DisordersInfectious Disease

Partners

NovartisAmgenAlexionMerckGileadMorphoSys/Incyte
SIMILAR COMPANIES
BASi Research Products
BASi Research Products
Pre-clinical · West Lafayette
Bay BioSciences
Bay BioSciences
Pre-clinical · San Francisco
EydisBio
EydisBio
Pre-clinical · Cambridge
3Spine
3Spine
Pre-clinical · Memphis
Belcher Pharmaceuticals
Belcher Pharmaceuticals
Pre-clinical · Miami
Is this your company?

Claim your profile to update information, add pipeline data, and connect with investors.

Claim profile