Verastem Oncology

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Verastem Oncology is a commercial-stage biotech company with a mission to develop novel treatments for RAS/MAPK pathway-driven cancers, a major oncogenic driver in ~30% of human cancers. Its key achievement is the FDA approval of avutometinib (a RAF/MEK clamp) combined with defactinib for KRAS-mutant recurrent low-grade serous ovarian cancer (LGSOC). The company's strategy is built on a deep understanding of pathway biology, pursuing rational drug combinations to block primary drivers and compensatory resistance, and forging strategic partnerships to accelerate development in high-unmet-need oncology areas.

A proprietary platform focused on the RAS/MAPK pathway, centered on avutometinib, a first-in-class small molecule RAF/MEK clamp that uniquely inhibits two nodes of the pathway simultaneously, combined with rational pairing of other agents like FAK inhibitors to overcome resistance.