Unnatural Products

Unnatural Products is a private, pre-clinical stage biotech leveraging a proprietary, integrated platform for the design and optimization of synthetic macrocyclic peptides. The company's technology, born out of academic research from the Lokey Lab, combines digital and physical lab tools in an iterative loop to rapidly generate drug-like candidates for traditionally intractable targets. UNP is advancing a targeted internal portfolio while also engaging in strategic partnerships with pharmaceutical leaders to apply its modality to high-value biology in oncology, immunology, cardiovascular, and rare diseases.

Integrated platform combining AI/ML-driven design, mRNA display libraries, and high-throughput synthesis/testing in a continuous optimization loop to engineer synthetic macrocyclic peptides with drug-like properties (potency, selectivity, permeability).

UNP competes in the cyclic peptide/macrocycle space with public companies like Bicycle Therapeutics (BTCX) and PeptiDream, as well as numerous private biotechs and large pharma internal efforts. Differentiation hinges on UNP's specific platform approach to synthetic, orally available macrocycles and its focus on a continuous AI/ML-driven optimization loop.