Travere Therapeutics

Travere Therapeutics

TVTXApproved

Travere Therapeutics is a publicly traded biopharma company singularly focused on rare diseases, particularly in nephrology and metabolism. Its strategic pipeline includes the commercially available therapy for IgA nephropathy and late-stage investigational candidates for FSGS and classical homocystinuria, aiming to set new standards of care. The company operates with a deep sense of urgency, guided by its 'In Rare For Life' ethos and a leadership team that includes rare disease patients and survivors, fostering strong community and advocacy partnerships.

Market Cap
$2.5B
Employees
450+
Focus
Biologics

TVTX · Stock Price

USD 26.98+1.75 (+6.94%)

Historical price data

AI Company Overview

Travere Therapeutics is a publicly traded biopharma company singularly focused on rare diseases, particularly in nephrology and metabolism. Its strategic pipeline includes the commercially available therapy for IgA nephropathy and late-stage investigational candidates for FSGS and classical homocystinuria, aiming to set new standards of care. The company operates with a deep sense of urgency, guided by its 'In Rare For Life' ethos and a leadership team that includes rare disease patients and survivors, fostering strong community and advocacy partnerships.

Technology Platform

Travere's core approach is patient-centric drug development and commercialization in niche rare diseases, focusing on strategic target identification, late-stage clinical development, and integrated advocacy to support diagnosis and care.

Pipeline Snapshot

14

14 drugs in pipeline, 5 in Phase 3

DrugIndicationStageWatch
SparsentanProteinuriaApproved
sparsentan + IrbesartanFocal Segmental GlomerulosclerosisPhase 3
PegtibatinaseHomocystinuriaPhase 3
sparsentan + irbesartan + DapagliflozinImmunoglobulin A NephropathyPhase 3
Fosmetpantotenate + PlaceboPantothenate Kinase-Associated NeurodegenerationPhase 3

Funding History

3

Total raised: $115M

Series B$35MUndisclosedJun 15, 2005
IPO$60MUndisclosedDec 12, 2003
Series A$20MUndisclosedJun 15, 2002

FDA Approved Drugs

1
FILSPARINDAFeb 17, 2023

Opportunities

Growth opportunities include maximizing the commercial potential of FILSPARI in IgAN, achieving regulatory approval for sparsentan in the untreated FSGS market, and pioneering the first disease-modifying therapy for Classical Homocystinuria.
Further expansion could come from business development to in-license or acquire additional rare disease assets.

Risk Factors

Key risks include commercial execution challenges for FILSPARI, clinical trial failures in late-stage FSGS or HCU programs, regulatory setbacks, and the financial pressure of funding commercialization and R&D simultaneously in a competitive capital environment.

Competitive Landscape

In IgAN, Travere competes with other therapies like SGLT2 inhibitors and Novartis's atrasentan. In FSGS, it aims to be first-to-market against generic standards of care. For HCU, it faces little direct pharmacological competition. Differentiation is built on rare disease specialization, patient advocacy, and a comprehensive support ecosystem.

Publications
18
Patents
1
Pipeline
14
FDA Approvals
1

Company Info

TypeTherapeutics
Employees450+
LocationSan Diego, United States
StageApproved
RevenueRevenue Generating

Trading

TickerTVTX
ExchangeNASDAQ

Therapeutic Areas

Rare Kidney DiseaseRare Metabolic DiseaseNephrology

Partners

NephCure Kidney InternationalInternational Cystinuria FoundationIgA Nephropathy FoundationHCU Network America (HCUNA)HCU Network AustraliaALD AllianceNational Organization for Rare Disorders (NORD)Rare Disease Diversity Coalition (Black Women’s Health Imperative)EveryLife Foundation for Rare Diseases
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