Sutro Biopharma

Sutro Biopharma

STROPhase 2
South San Francisco, United Statessutrobio.com

Sutro Biopharma is redefining cancer therapy through its innovative cell-free protein synthesis platform, XpressCF®, which allows for the rational design of optimized antibody-drug conjugates (ADCs). The company's core strategy involves developing single- and dual-payload ADCs aimed at overcoming treatment resistance and expanding the range of treatable tumors. With a public listing on NASDAQ and a leadership team rich in biotech experience, Sutro is advancing a clinical pipeline while leveraging its platform through strategic collaborations to create meaningful breakthroughs for patients.

Market Cap
$338.9M
Focus
Biologics

STRO · Stock Price

USD 20.6862.12 (-75.02%)

Historical price data

AI Company Overview

Sutro Biopharma is redefining cancer therapy through its innovative cell-free protein synthesis platform, XpressCF®, which allows for the rational design of optimized antibody-drug conjugates (ADCs). The company's core strategy involves developing single- and dual-payload ADCs aimed at overcoming treatment resistance and expanding the range of treatable tumors. With a public listing on NASDAQ and a leadership team rich in biotech experience, Sutro is advancing a clinical pipeline while leveraging its platform through strategic collaborations to create meaningful breakthroughs for patients.

Technology Platform

Proprietary cell-free protein synthesis platform (XpressCF®) that enables precise design and manufacturing of novel protein therapeutics, including site-specific, homogeneous antibody-drug conjugates (ADCs) and dual-payload ADCs.

Pipeline Snapshot

7

7 drugs in pipeline

DrugIndicationStage
Luveltamab tazevibulinLung CancerPhase 2
STRO-002Neoplasm MalignantPhase 1/2
Luveltamab tazevibulinAcute Myeloid Leukemia (AML)Phase 1/2
STRO-002 + BevacizumabOvarian CancerPhase 1
STRO-001B-cell LymphomaPhase 1

Funding History

6

Total raised: $394M

PIPE$120MUndisclosedJun 15, 2020
IPO$85MUndisclosedOct 18, 2018
Series D$72MSkyline VenturesJun 15, 2017
Series C$47MSkyline VenturesJun 15, 2014

Opportunities

The primary growth opportunity is the successful development and commercialization of luveltamab tazevibulin in ovarian and other FolRα+ cancers, targeting a large market with high unmet need.
Additionally, the proprietary XpressCF® platform presents significant value through the creation of novel dual-payload ADCs and the potential for multiple high-value partnerships with other biopharma companies.

Risk Factors

Key risks include clinical trial failure of the lead asset, intense competition in the ADC therapeutic area, the need to raise additional capital leading to shareholder dilution, and the technical and regulatory challenges of scaling its novel cell-free manufacturing process.

Competitive Landscape

Sutro competes in the crowded ADC space against large pharma (e.g., AstraZeneca, Gilead) and biotech peers. Its main differentiation is the XpressCF® platform, which enables precise, homogeneous ADC construction and the novel dual-payload approach, aiming to overcome resistance mechanisms that limit current therapies.

Publications
18
Patents
20
Pipeline
7

Company Info

TypeTherapeutics
LocationSouth San Francisco, United States
StagePhase 2
RevenuePre-revenue

Trading

TickerSTRO
ExchangeNASDAQ

Therapeutic Areas

Oncology

Partners

AstellasMerck KGaABristol Myers Squibb (legacy)
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