SeSaM-Biotech

SeSaM-Biotech is a private, revenue-generating contract research organization (CRO) focused exclusively on providing directed evolution services to optimize enzymes for clients. The company's business model is built on a fee-for-service basis, offering clients full intellectual property ownership of the evolved enzymes without royalties or licenses. Its validated, patented technology platform and transparent project management have attracted a diverse clientele, positioning it as a specialized partner in the synthetic biology and industrial biotechnology sectors. The company operates from its headquarters in Aachen, Germany, leveraging a network of scientific expertise.

Patented SeSaM (Sequence Saturation Mutagenesis) technology and the proprietary KnowVolution strategy for directed enzyme evolution, combining random mutagenesis with knowledge-driven, iterative protein engineering.

Competes with other protein engineering CROs (e.g., Arzeda, Proteinea, industrial divisions of large enzyme producers like Novozymes) and academic tech transfer services. Differentiation is based on patented SeSaM/KnowVolution technology, full IP transfer to clients, and a transparent, high-touch service model focused exclusively on directed evolution.