Rigel Pharmaceuticals

Rigel Pharmaceuticals

RIGLApproved
South San Francisco, United StatesFounded 1996rigel.com

Rigel Pharmaceuticals is a commercial-stage biotech with a strategic focus on hematology and oncology, building a portfolio of approved and investigational therapies. The company has successfully brought multiple products to market, including TAVALISSE for ITP and REZLIDHIA for AML, and is advancing a pipeline through both internal R&D and strategic collaborations, such as its partnership with Eli Lilly on a RIPK1 inhibitor. Headquartered in South San Francisco, Rigel operates as a public company (NASDAQ: RIGL) and is led by a seasoned management team with deep experience in biopharma development and commercialization.

Market Cap
$480.3M
Founded
1996
Focus
Small Molecules

RIGL · Stock Price

USD 26.0060.20 (-69.84%)

Historical price data

AI Company Overview

Rigel Pharmaceuticals is a commercial-stage biotech with a strategic focus on hematology and oncology, building a portfolio of approved and investigational therapies. The company has successfully brought multiple products to market, including TAVALISSE for ITP and REZLIDHIA for AML, and is advancing a pipeline through both internal R&D and strategic collaborations, such as its partnership with Eli Lilly on a RIPK1 inhibitor. Headquartered in South San Francisco, Rigel operates as a public company (NASDAQ: RIGL) and is led by a seasoned management team with deep experience in biopharma development and commercialization.

Technology Platform

Small molecule drug discovery focused on intracellular signaling pathways, particularly kinases and enzymes involved in hematologic disorders, cancer, and immune dysregulation.

Pipeline Snapshot

38

38 drugs in pipeline, 6 in Phase 3

DrugIndicationStage
Olutasidenib + CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, and OATP1B1 Prob...AML (Acute Myeloid Leukemia)Approved
Fostamatinib disodium + PlaceboWarm Antibody Autoimmune Hemolytic AnemiaPhase 3
Fostamatinib disodium + PlaceboImmune Thrombocytopenic PurpuraPhase 3
Fostamatinib disodiumWarm Antibody Autoimmune Hemolytic AnemiaPhase 3
Fostamatinib DisodiumImmune Thrombocytopenic PurpuraPhase 3

Funding History

2

Total raised: $92M

PIPE$50MUndisclosedDec 15, 2019
IPO$42MUndisclosedFeb 3, 2000

FDA Approved Drugs

3
REZLIDHIANDADec 1, 2022
GAVRETONDASep 4, 2020
TAVALISSENDAApr 17, 2018

Opportunities

Growth opportunities include expanding the label and geographic reach of TAVALISSE and REZLIDHIA, successfully advancing the IRAK1/4 inhibitor in MDS, and leveraging the Eli Lilly partnership to develop the RIPK1 inhibitor in immunology.
Further pipeline expansion through internal research and strategic acquisitions presents additional avenues for growth.

Risk Factors

Key risks include commercial competition for approved products, clinical trial failures for pipeline candidates, regulatory setbacks, dependence on a limited number of products for revenue, and potential challenges in securing and maintaining favorable reimbursement.

Competitive Landscape

Rigel competes with larger pharmaceutical companies in ITP (e.g., Amgen with Nplate, Novartis with Promacta) and AML (e.g., Servier with Tibsovo). Its differentiation lies in its focused hematology/oncology expertise, targeted mechanisms of action (SYK, IDH1 inhibition), and oral small molecule formulations. In pipeline areas like MDS and immunology, it faces competition from both biotech and pharma entities developing novel pathway inhibitors.

Publications
20
Patents
20
Pipeline
38
FDA Approvals
3

Company Info

TypeTherapeutics
Founded1996
LocationSouth San Francisco, United States
StageApproved
RevenueRevenue Generating

Trading

TickerRIGL
ExchangeNASDAQ

Therapeutic Areas

HematologyOncologyImmunology

Partners

Eli Lilly and Company
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