Resolve Biosciences

Resolve Biosciences is a private, commercial-stage company pioneering high-resolution spatial biology through its Molecular Cartography™ platform. The technology leverages true single-molecule RNA fluorescence in situ hybridization (smFISH) to map complex tissue ecosystems at subcellular resolution without the need for tissue clearing or signal amplification. The company targets the rapidly growing spatial biology and diagnostics market, with a primary focus on immuno-oncology, tumor pathology, and therapeutic development. Its end-to-end solution aims to translate spatial insights into clinically relevant biomarkers for improved patient stratification and treatment strategies.

Molecular Cartography™: An end-to-end spatial biology platform using true single-molecule RNA FISH (smFISH) for multi-modal profiling of RNA, protein, and morphology on the same FFPE tissue section without clearing or signal amplification.

Resolve competes in the crowded spatial biology market against major players like 10x Genomics (Visium/Xenium), NanoString (GeoMx/DSP), Akoya Biosciences (PhenoCycler/CODEX), and Vizgen (MERSCOPE). Its differentiation hinges on true single-molecule RNA detection without amplification, a streamlined workflow, and integrated multi-modal analysis on a single section.