Rapport Therapeutics

Rapport Therapeutics

RAPPPhase 2

Rapport Therapeutics is advancing a new class of precision medicines for brain disorders by targeting specific receptor-associated proteins (RAPs) to achieve unprecedented selectivity and therapeutic windows. The company's lead candidate, RAP-219, is a GABA-A receptor-associated protein modulator in Phase 1b/2a development for drug-resistant focal epilepsy, with a broader pipeline targeting other neurological conditions. Founded by industry veterans and backed by a strong syndicate, Rapport leverages deep neuroscience expertise to address high-unmet-need disorders with its innovative platform.

Market Cap
$1.3B
Employees
50-100
Focus
Biotech

RAPP · Stock Price

USD 27.08+6.28 (+30.19%)

Historical price data

AI Company Overview

Rapport Therapeutics is advancing a new class of precision medicines for brain disorders by targeting specific receptor-associated proteins (RAPs) to achieve unprecedented selectivity and therapeutic windows. The company's lead candidate, RAP-219, is a GABA-A receptor-associated protein modulator in Phase 1b/2a development for drug-resistant focal epilepsy, with a broader pipeline targeting other neurological conditions. Founded by industry veterans and backed by a strong syndicate, Rapport leverages deep neuroscience expertise to address high-unmet-need disorders with its innovative platform.

Technology Platform

A precision neuroscience platform developing small molecule modulators that target specific receptor-associated proteins (RAPs) to achieve circuit-selective therapeutic effects for neurological and psychiatric disorders.

Pipeline Snapshot

3

3 drugs in pipeline

DrugIndicationStageWatch
RAP-219Focal Onset SeizuresPhase 2
RAP-219Focal EpilepsyPhase 2
RAP-219Bipolar 1 DisorderPhase 2

Funding History

3

Total raised: $523.5M

IPO$273.5MUndisclosedJun 27, 2024
Series B$150MCormorant Asset ManagementJun 15, 2023
Series A$100MThird Rock VenturesJan 15, 2022

Opportunities

The primary near-term opportunity is to clinically validate the RAP platform with positive data for RAP-219 in epilepsy, which would unlock significant value and enable expansion into larger adjacent markets like anxiety disorders.
Long-term, the platform technology offers the potential to develop a pipeline of precision medicines for a wide range of CNS conditions with high unmet need.

Risk Factors

Key risks include the clinical failure of the novel RAP-219 mechanism in ongoing trials, the inherent difficulty of developing drugs for complex neurological disorders, and intense competition in the CNS therapeutic landscape.
As a newly public company, Rapport also faces execution risk and market volatility.

Competitive Landscape

Rapport's main competitors are large pharma and biotechs developing novel therapies for epilepsy and anxiety (e.g., Marinus, Neurocrine, Biogen). Rapport differentiates itself through its unique RAP-targeting platform, which aims to achieve circuit-specific modulation of key receptors, potentially offering superior efficacy and tolerability compared to broad-acting standard-of-care drugs.

Publications
2
Patents
1
Pipeline
3

Company Info

TypeTherapeutics
Founded2022
Employees50-100
LocationBoston, United States
StagePhase 2
RevenuePre-revenue

Trading

TickerRAPP
ExchangeNASDAQ

Therapeutic Areas

NeurosciencePsychiatryEpilepsyAnxiety DisordersCognitive Disorders

Partners

Johnson & Johnson Innovation
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