Quivive Pharma

Quivive Pharma

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Private Company

Funding information not available

Overview

Quivive Pharma is a private, preclinical-stage biotech addressing the opioid overdose epidemic through a novel drug delivery and safety platform. Its lead strategy involves repurposing Doxapram, an FDA-approved drug, as a functional antagonist to counteract opioid-induced respiratory depression—the primary cause of overdose deaths—while preserving analgesia. The company aims to develop abuse-deterrent opioid formulations that close a significant safety gap left by current products and address the major gateway to opioid addiction.

OncologyInflammatory DiseasesPainOpioid-Induced Respiratory Depression

Technology Platform

Functional antagonism platform using Doxapram to counteract opioid-induced respiratory depression and other side effects without impacting analgesia, combined with a pharmacological abuse-deterrence technology.

Opportunities

The massive, unmet need in the opioid crisis creates a compelling market for a product that can prevent overdose deaths while preserving pain relief.
Regulatory agencies are incentivized to support safer opioid technologies, and success with a first product could enable a platform applied to multiple opioids.

Risk Factors

High clinical and regulatory risk in proving safety and efficacy of a respiratory-affecting combination drug.
Commercial adoption risk is significant due to the overall trend away from opioid prescribing.
Competition from non-opioid analgesics and other novel mechanisms poses a long-term threat.

Competitive Landscape

Competes against developers of non-opioid analgesics, novel opioid agonists with improved safety profiles, and existing abuse-deterrent formulations (which Quivive argues are insufficient). Also faces competition from naloxone-based rescue therapies, which are reactive rather than preventive.