Potentiometric Probes

Potentiometric Probes is a private, early-stage company commercializing a platform of voltage-sensitive dyes (VSDs) for optical electrophysiology. Its core technology, rooted in the pioneering work of co-founder Dr. Leslie Loew, offers researchers sensitive, ratiometric imaging tools to study electrical signaling in the brain, heart, and other systems without invasive electrodes. The company operates a direct-to-research sales model, providing critical chemical tools and support to accelerate basic science and pre-clinical drug screening. While currently a niche supplier, its advanced dye chemistries position it at the intersection of growing markets in functional imaging and phenotypic screening.

Platform of synthetic organic voltage-sensitive dyes (VSDs), including proprietary 'ElectroFluor' compounds, that enable optical recording of membrane potential changes in cells and tissues for research and drug screening.

Competes with life science reagent giants (e.g., Thermo Fisher) offering classic VSDs and with academic labs developing genetically encoded voltage indicators (GEVIs). Differentiation is based on proprietary, performance-optimized dye chemistry (ElectroFluor series), deep application expertise, and a focus on solving specific problems like motion artifact in cardiac imaging.