Plasticell

Plasticell

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Private Company

Total funding raised: $21.3M

Overview

Plasticell is a private biotechnology company pioneering a high-throughput combinatorial screening platform, CombiCult®, to rapidly develop optimized cell culture protocols for regenerative medicine. Its therapeutic pipeline is centered on advanced cell and gene therapies, including iPSC-derived allogeneic cancer immunotherapies, hematopoietic stem cell expansion, and treatments for thrombocytopenia and anemia. The company operates through a collaborative business model, partnering with academic and industry leaders like Imperial College London and the Cell and Gene Therapy Catapult to advance its programs and manufacturing capabilities.

OncologyRare DiseasesHematology

Technology Platform

CombiCult® - A combinatorial high-throughput screening platform that tests thousands of cell culture variable combinations simultaneously to rapidly discover optimized protocols for stem cell expansion, differentiation, and gene transduction. Supported by Ariadne® bioinformatics software.

Funding History

3
Total raised:$21.3M
Series B$12M
Grant$800K
Series A$8.5M

Opportunities

The global shift towards off-the-shelf (allogeneic) cell therapies presents a major opportunity for Plasticell's iPSC-derived immunotherapy platform.
Additionally, its CombiCult® technology can be leveraged through partnerships with other biopharma companies seeking to optimize their own cell therapy manufacturing processes, creating potential non-dilutive revenue streams.

Risk Factors

Key risks include the scientific and technical challenges of scaling iPSC-derived therapies and demonstrating clinical safety/efficacy.
As a pre-revenue private company, Plasticell also faces significant funding risk and operates in a highly competitive landscape with well-capitalized rivals in both platform technology and therapeutic development.

Competitive Landscape

Plasticell competes with other cell therapy platform companies (e.g., using CRISPR, other screening methods) and direct therapeutic developers in allogeneic CAR-T/iPSC-derived cells (e.g., Fate Therapeutics, Century Therapeutics) and hematopoietic stem cell expansion (e.g., Gamida Cell). Its differentiation lies in the high-throughput, combinatorial nature of the CombiCult® platform for process optimization.