Pangolin Therapeutics
Pre-clinicalIDPs are unstructured proteins, lacking the stable binding pockets needed for small molecule therapeutics, making them traditionally undruggable targets. Examples are: Islet amyloid polypeptide (IAPP), in the case of Type 2 Diabetes; alpha-synuclein, in the case of Parkinson’s Disease; and Myc, in the case of several tumors. During disease progression, IDPs miss-assemble and become toxic to cells.
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IDPs are unstructured proteins, lacking the stable binding pockets needed for small molecule therapeutics, making them traditionally undruggable targets. Examples are: Islet amyloid polypeptide (IAPP), in the case of Type 2 Diabetes; alpha-synuclein, in the case of Parkinson’s Disease; and Myc, in the case of several tumors. During disease progression, IDPs miss-assemble and become toxic to cells.
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