Pacific Biosciences

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Pacific Biosciences (PACB) is a public biotechnology company whose mission is to democratize access to highly accurate long-read sequencing to unlock complex genetic insights. The company has achieved a critical technological moat with its HiFi sequencing, which delivers Sanger-like accuracy (99.9%) in reads up to 25 kilobases, making it a gold standard for detecting all variant types and phasing haplotypes. Its strategy centers on a vertically integrated platform of instruments, consumables, and software, driving recurring revenue while expanding into scalable clinical research and population genomics through throughput innovations like the Revio system and Kinnex kits.

Proprietary Single Molecule, Real-Time (SMRT) sequencing technology, which generates highly accurate long reads (HiFi reads) by observing individual DNA polymerase molecules in real-time within zero-mode waveguides (ZMWs), enabling detection of all variant types and base modifications.