Navigation Sciences

Navigation Sciences is a private, pre-revenue medical device company founded in 2016 and based in Brookline, MA (with a listed office in San Jose, CA). The company is developing the NaviSci System, an augmented reality-guided surgical platform that provides real-time, in-vivo margin measurement during soft tissue cancer resections. It has completed a 25-patient clinical feasibility trial in early-stage lung cancer to support an FDA submission and was recently selected as a 2025 'Best Start-up' candidate by the Prix Galien Foundation. The technology originated from Brigham & Women's Hospital and Harvard Medical School.

The NaviSci System integrates augmented reality (AR) visualization, advanced software algorithms, and surgical hardware to provide real-time, in-vivo measurement of tumor margins during minimally invasive cancer surgery. It tracks surgical instruments and registers them to pre-operative 3D CT models, offering GPS-like navigation for precise resection.

The competitive landscape includes large players in surgical robotics (e.g., Intuitive Surgical) and surgical navigation (e.g., Medtronic, Brainlab). However, Navigation Sciences is carving a niche with a specific focus on real-time quantitative margin assessment for soft tissue oncology, a feature not fully addressed by current mainstream systems.