iRepertoire

iRepertoire is a private, revenue-generating company offering a full-stack platform for adaptive immune receptor profiling. Its core technology, dam-PCR, allows for the simultaneous amplification and error-corrected sequencing of all seven TCR and BCR chains from bulk samples, while its iPair platform enables single-cell, paired-chain analysis. The company serves as a specialized service and technology provider for academic, biopharma, and clinical researchers, focusing on delivering high-quality data and analytical partnership rather than developing its own therapeutics. Its solutions are applied across key areas including therapy monitoring, cell therapy optimization, and vaccine development.

Proprietary dam-PCR (duplex anchoring multiplex PCR) for error-corrected, multi-chain bulk immune repertoire sequencing (RepSeq+), and the iPair platform for single-cell, paired-chain V(D)J analysis from FACS-sorted cells.

iRepertoire competes with large NGS tool providers like 10x Genomics (single-cell immune profiling) and Adaptive Biotechnologies (immune sequencing and clinical diagnostics), as well as numerous academic and commercial bioinformatics service providers. Its differentiation lies in its specialized 7-chain bulk sequencing and focused single-cell pairing service.