GRAIL

GRAIL

GRALPre-clinical
Founded 2015grail.com

GRAIL is a mission-driven company leveraging next-generation sequencing, population-scale clinical studies, and advanced machine learning to detect cancer early when it may be more treatable. Its clinical program has enrolled over 300,000 participants, and its Galleri test is at the forefront of the MCED category. The company is publicly traded and is focused on commercializing Galleri, expanding clinical utility evidence, and pursuing partnerships to integrate its test into healthcare systems globally.

Market Cap
$2.0B
+57.5% period
Pipeline
Patents
20
granted
Publications
19
indexed

GRAL · Stock Price

USD 49.13+17.93 (+57.47%)

Historical price data

AI Company Overview

GRAIL is a mission-driven company leveraging next-generation sequencing, population-scale clinical studies, and advanced machine learning to detect cancer early when it may be more treatable. Its clinical program has enrolled over 300,000 participants, and its Galleri test is at the forefront of the MCED category. The company is publicly traded and is focused on commercializing Galleri, expanding clinical utility evidence, and pursuing partnerships to integrate its test into healthcare systems globally.

Oncology

Technology Platform

A multi-cancer early detection platform using next-generation sequencing of cell-free DNA methylation patterns combined with machine learning to identify a shared cancer signal and predict its tissue of origin from a single blood draw.

Funding History

3
Total raised:$1.4B
IPO$390MJun 15, 2021
Series B$900MMar 15, 2017
Series A$100MJan 15, 2016

Opportunities

The primary growth opportunity lies in securing broad insurance reimbursement for the Galleri test, which would unlock the massive addressable market of adults over 50.
Additional opportunities include expanding into international markets, developing risk-stratified screening protocols, and exploring applications in minimal residual disease (MRD) detection and therapy monitoring through its platform technology.

Risk Factors

Key risks include failure to secure adequate insurance reimbursement, which is critical for adoption; the potential for longer-term mortality data from clinical trials to be less compelling than early-stage shift data; intense and well-funded competition in the MCED space; and the clinical and economic challenges of managing false-positive results and the associated diagnostic follow-up cascade.

Competitive Landscape

GRAIL competes in the emerging Multi-Cancer Early Detection (MCED) market against companies like Exact Sciences, Guardant Health, Freenome, and Delfi Diagnostics. Its key differentiator is its extensive clinical evidence base, including the large, randomized NHS-Galleri trial, which provides a significant head start in demonstrating real-world utility to payers and clinicians.