Gilgamesh Pharmaceuticals

Gilgamesh Pharmaceuticals

Is this your company? Claim your profile to update info and connect with investors.
Claim profile

Private Company

Total funding raised: $110M

Overview

Gilgamesh Pharmaceuticals is a private, clinical-stage biotech leveraging a proprietary AI-powered discovery platform to develop next-generation, non-hallucinogenic neuroplastogens and other novel compounds for major depressive disorder, anxiety, and opioid use disorder. The company has advanced multiple candidates into Phase 2 trials, secured a significant collaboration with AbbVie, and is backed by notable investors like Y Combinator and Prime Movers Lab. With a seasoned leadership team from top biopharma and academia, Gilgamesh is positioned at the forefront of the emerging precision psychiatry sector, aiming to address the global mental health crisis with safer, more effective therapies.

Major Depressive DisorderAnxiety DisordersOpioid Use DisorderPsychiatric Diseases

Technology Platform

Proprietary AI-powered discovery and translational platform utilizing complex behavioral assessment, advanced electrophysiology, molecular neuroplasticity measures, and machine learning to optimize novel psychoactive drug candidates.

Funding History

2
Total raised:$110M
Series B$71M
Series A$39M

Opportunities

The massive unmet need in mental health creates a multi-billion dollar market for novel, effective therapies.
Gilgamesh's focus on non-hallucinogenic, orally available compounds could enable broader, safer, and more scalable treatment paradigms compared to first-generation psychedelics.
Strategic partnerships with large pharma, as evidenced by the AbbVie deal, provide significant validation, funding, and a path to commercialization.

Risk Factors

The company faces high clinical development risk, as novel mechanisms may fail in later-stage trials.
The competitive landscape in psychedelic-inspired medicine is crowded and rapidly evolving.
Regulatory pathways for these new chemical entities, while taking shape, remain less defined than for conventional antidepressants.

Competitive Landscape

Gilgamesh competes in the rapidly growing neuroplastogen and psychedelic-inspired medicine sector against public companies like Compass Pathways (COMP360), Cybin (CYB003), and ATAI Life Sciences, as well as numerous private biotechs. Its key differentiation lies in its AI-driven platform to engineer non-hallucinogenic compounds and its strategic partnership with a major pharma player, AbbVie.