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Entirety Biomedical

Entirety Biomedical

Cambridge, United States· Est.
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Private Company

Total funding raised: $3.2M

Overview

Entirety Biomedical is a private, pre-revenue medical device startup founded in 2021 and based in Cambridge, Massachusetts. The company's core innovation is Curasorb, a patent-pending, absorbable magnesium alloy platform engineered to be a direct, 'plug-and-play' replacement for permanent titanium implants in bone fixation procedures. By combining the mechanical reliability of metal with safe absorption, Entirety aims to address the lifelong patient complications and costs associated with permanent hardware, positioning its technology as a potential new standard of care in surgical fixation. The company is led by industry veterans and is in the product development and preclinical validation stage.

OrthopedicsMaxillofacial SurgerySports Medicine

Technology Platform

Curasorb, a proprietary absorbable magnesium alloy platform engineered to match the mechanical performance and handling of titanium implants, then safely absorb in the body after bone healing.

Funding History

1
Total raised:$3.2M
Seed$3.2M

Opportunities

The global market for temporary surgical fixation is large and underserved, with permanent implants causing long-term complications.
Curasorb's 'plug-and-play' design for surgeons and coverage under existing reimbursement codes significantly lower barriers to adoption.
The platform technology allows expansion into multiple high-value surgical markets beyond the initial focus areas.

Risk Factors

The company faces significant technical risk in perfectly tuning the implant absorption rate to match bone healing, and regulatory risk in obtaining FDA clearance.
As a pre-revenue startup, it is dependent on external funding.
Commercialization risk is high, requiring displacement of entrenched titanium implants and competition from large medtech incumbents and other absorbable metal developers.

Competitive Landscape

Entirety competes with large medtech companies selling permanent titanium implants (e.g., Stryker, Johnson & Johnson) and makers of resorbable polymer implants. Its direct competitors are other developers of absorbable magnesium alloys, though it claims a performance and IP advantage. The key differentiator is achieving titanium-like strength with safe absorption, a niche not yet filled.

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