Enspire DBS Therapy

Enspire DBS Therapy is pioneering the application of deep brain stimulation for chronic stroke rehabilitation, a significant expansion of DBS beyond its traditional neurological indications. The company is currently conducting a pivotal Phase 2/3 clinical trial (RESTORE) to evaluate the safety and efficacy of its DBS system plus rehab for improving arm function. Backed by a $10.3M Series B1 financing round in early 2026, Enspire is advancing its technology through clinical development. Positive early feasibility data published in Nature Medicine in 2023 supports its novel therapeutic hypothesis.

Implantable deep brain stimulation (DBS) system targeting the cerebellar dentate nucleus to promote neural plasticity and motor recovery when combined with rehabilitation therapy.

Competition includes other investigational neuromodulation approaches for stroke, such as cortical stimulation (e.g., from companies like Helius Medical) and vagus nerve stimulation (e.g., MicroTransponder). It also faces competition from advanced rehabilitation robotics and non-invasive brain stimulation techniques. Enspire's deep brain targeting is a distinct and more invasive approach.