Enliven Therapeutics

Enliven Therapeutics

ELVN
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ELVN · Stock Price

USD 40.29+21.87 (+118.73%)
Market Cap: $2.6B

Historical price data

Overview

Enliven Therapeutics is a clinical-stage biotech focused on developing precision small molecule kinase inhibitors to help cancer patients live longer and better lives. The company leverages a deep expertise in kinase biology and medicinal chemistry to create highly selective, combinable drugs that overcome resistance and address unmet needs. With a lead asset, ELVN-001, showing positive initial Phase 1b data in CML and a robust pipeline, Enliven is strategically positioned to advance novel therapies in competitive oncology markets.

Oncology

Technology Platform

A rational design platform for next-generation small molecule kinase inhibitors, focusing on enhanced selectivity, combinability, resistance management, CNS penetration, and improved safety profiles.

Pipeline

4
4 drugs in pipeline
DrugIndicationStageWatch
ELVN-001Chronic Myeloid LeukemiaPhase 1
ELVN-002 + Fam-Trastuzumab Deruxtecan-Nxki + Trastuzumab emt...HER2 Mutant Non-small Cell Lung CancerPhase 1
ELVN-002 + Trastuzumab + 5-Fluorouracil + Oxaliplatin + Cape...HER2-positive Breast CancerPhase 1
ELVN-001CML (Chronic Myelogenous Leukemia)Phase 1

Funding History

3
Total raised:$338M
IPO$168M
Series B$115M
Series A$55M

Opportunities

The primary opportunity is establishing ELVN-001 as a best-in-class therapy for CML, particularly in resistant or niche populations, before expanding into broader markets.
The platform's ability to generate CNS-penetrant inhibitors also opens a significant opportunity in treating solid tumor brain metastases, a major unmet need.

Risk Factors

Key risks include clinical failure of the lead asset ELVN-001, intense competition in established markets like CML, high dependency on a single program, and the future need for dilutive financing to advance the pipeline.

Competitive Landscape

Enliven faces intense competition from large pharma and biotech companies with approved and pipeline kinase inhibitors. Its differentiation relies on superior drug design (selectivity, CNS penetration) and a team with a proven track record of discovering successful drugs in this class.