Diagnostic Biochips

Diagnostic Biochips is a private company that leverages semiconductor-based silicon probe technology to enable real-time, high-density electrophysiological recordings from within intact 3D neural cultures like brain organoids. Its flagship SomaFocus platform integrates automated hardware, AI-driven data processing, and real-time visualization to provide functional insights for neurological disease research and drug discovery. Founded in 2012, the company targets the growing need for more physiologically relevant, human-based preclinical models to bridge the gap between in-vitro experimentation and clinical neuroscience.

SomaFocus platform: An integrated system using semiconductor-fabricated silicon probes for high-density, real-time electrophysiological recording from within intact 3D tissues like brain organoids. It combines automated hardware, AI-driven data processing, and real-time visualization.

Competitors include traditional multi-electrode array (MEA) system providers (e.g., Axion Biosystems, MaxWell Biosystems) that record from tissue surfaces, and companies developing advanced in-vivo electrophysiology tools (e.g., Neuropixels). Diagnostic Biochips differentiates by specializing in deep, high-resolution recording from *intact* 3D tissues with a streamlined workflow, a niche not fully addressed by surface MEAs or invasive traditional techniques.