DepYmed

DepYmed

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Private Company

Total funding raised: $40M

Overview

DepYmed is a clinical-stage biotech leveraging a proprietary platform to develop selective inhibitors of protein tyrosine phosphatase 1B (PTP1B) and copper chelators. The company is advancing two orally bioavailable small molecules into clinical trials, with its lead asset, DPM-1003 for Rett Syndrome, having recently received FDA clearance to initiate a Phase 1 trial. With a focus on rare diseases and oncology, DepYmed is backed by venture capital and led by a team with deep expertise in drug development and phosphatase biology.

Rett SyndromeOncologyWilson DiseaseMetabolic DiseasesNeurodegenerative Diseases

Technology Platform

Platform for developing selective small molecule inhibitors of protein tyrosine phosphatase 1B (PTP1B) and novel copper chelating agents.

Funding History

2
Total raised:$40M
Series A$28M
Seed$12M

Opportunities

The lead program in Rett Syndrome addresses a severe rare disease with no approved disease-modifying treatments, offering a potential accelerated pathway.
Success in initial indications could validate the PTP1B platform for much larger markets in metabolic and inflammatory diseases.

Risk Factors

The novel mechanism of PTP1B inhibition carries unproven clinical safety and efficacy risk in humans.
As a pre-revenue private company, DepYmed is dependent on raising additional capital to fund costly clinical development, exposing it to financing risk.

Competitive Landscape

In Rett Syndrome, competition includes gene therapy and other symptomatic approaches, but few direct PTP1B inhibitors. In Wilson Disease, DepYmed's novel chelator would compete against existing standard-of-care drugs and other next-generation agents in development. The oncology PTP1B inhibitor space is emerging with limited direct competitors.