Cyclo Therapeutics

Cyclo Therapeutics

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Private Company

Total funding raised: $30M

Overview

Cyclo Therapeutics is a US-based biotech leveraging cyclodextrin chemistry to create novel treatments for challenging diseases, with its most advanced candidate, Trappsol® Cyclo™, in clinical development for Niemann-Pick Disease Type C. The company is expanding its pipeline to include Alzheimer's disease, aiming to address pathological protein aggregation. Founded in 2000, it operates as a public entity, driving programs from clinical trials towards potential regulatory approval. Its strategy centers on harnessing its proprietary drug delivery platform to improve therapeutic outcomes in underserved patient populations.

Niemann-Pick Disease Type CAlzheimer's Disease

Technology Platform

Proprietary cyclodextrin-based chemistry platform for mobilizing accumulated lipids and proteins, used as both active drug and drug delivery vehicle.

Funding History

2
Total raised:$30M
Series B$20M
Series A$10M

Opportunities

Approval in NPC offers a high-value orphan drug opportunity with potential for expedited regulatory pathways and market exclusivity.
The platform's application in Alzheimer's disease represents a massive market opportunity if clinical efficacy can be demonstrated in this challenging indication.

Risk Factors

High clinical trial failure risk for the pivotal Phase 3 NPC study, which is critical to company survival.
Significant financial risk as a pre-revenue company with substantial burn rate dependent on capital markets for funding.

Competitive Landscape

In NPC, competition includes other small molecules and gene therapies in development. In Alzheimer's, the landscape is intensely competitive with numerous large pharma and biotech companies targeting amyloid, tau, and other pathways, requiring superior efficacy or differentiation.