CRISPR Therapeutics

CRISPR Therapeutics

CRSPPhase 2

CRISPR Therapeutics is a pioneering biopharmaceutical company dedicated to discovering, developing, and commercializing curative gene-editing treatments. Founded by CRISPR gene-editing pioneers, the company leverages its proprietary CRISPR/Cas9 platform to create a diverse pipeline targeting hemoglobinopathies, immuno-oncology, regenerative medicine, and in vivo diseases. Its landmark achievement is the approval of CASGEVY, the world's first CRISPR/Cas9 gene-edited therapy, marking a new era in medicine and validating its platform's potential. The company collaborates with Vertex Pharmaceuticals and Bayer to accelerate development and commercialization across multiple therapeutic areas.

Market Cap
$4.4B
Employees
500-1000
Focus
Biotech

CRSP · Stock Price

USD 46.2415.90 (-25.59%)

Historical price data

AI Company Overview

CRISPR Therapeutics is a pioneering biopharmaceutical company dedicated to discovering, developing, and commercializing curative gene-editing treatments. Founded by CRISPR gene-editing pioneers, the company leverages its proprietary CRISPR/Cas9 platform to create a diverse pipeline targeting hemoglobinopathies, immuno-oncology, regenerative medicine, and in vivo diseases. Its landmark achievement is the approval of CASGEVY, the world's first CRISPR/Cas9 gene-edited therapy, marking a new era in medicine and validating its platform's potential. The company collaborates with Vertex Pharmaceuticals and Bayer to accelerate development and commercialization across multiple therapeutic areas.

Technology Platform

Proprietary CRISPR/Cas9 gene-editing platform enabling both ex vivo (cell therapy) and in vivo (direct administration) therapeutic approaches, with a focus on allogeneic (off-the-shelf) cell therapies.

Pipeline Snapshot

8

8 drugs in pipeline

DrugIndicationStageWatch
CTX112B-cell LymphomaPhase 1/2
CTX110B-cell MalignancyPhase 1/2
CTX131Clear Cell Renal Cell CarcinomaPhase 1/2
CTX131T Cell LymphomaPhase 1/2
CTX130Renal Cell CarcinomaPhase 1

Funding History

4

Total raised: $421M

PIPE$200MUndisclosedJul 15, 2020
IPO$56MUndisclosedOct 19, 2016
Series B$140MCelgeneNov 15, 2015
Series A$25MVersant VenturesOct 15, 2014

Opportunities

Significant growth opportunities exist in expanding CASGEVY's global reach and label, advancing its allogeneic CAR-T pipeline to address large oncology markets, and successfully translating its in vivo and regenerative medicine programs from research to clinic.
The validated platform enables rapid expansion into new genetic targets.

Risk Factors

Key risks include clinical failure of pipeline candidates, commercial challenges in launching complex, high-cost therapies like CASGEVY, manufacturing scalability, intense competition in gene editing and cell therapy, and potential long-term safety uncertainties associated with gene editing.

Competitive Landscape

Main competitors include bluebird bio in hemoglobinopathies, and Allogene Therapeutics, Caribou Biosciences, and Intellia Therapeutics in the broader gene-editing and allogeneic cell therapy space. CRISPR Therapeutics differentiates through its first-mover approval, integrated platform spanning ex vivo and in vivo approaches, and strong strategic partnerships.

Publications
20
Patents
20
Pipeline
8

Company Info

TypeTherapeutics
Founded2013
Employees500-1000
LocationZug, Switzerland
StagePhase 2
RevenueEarly Revenue

Trading

TickerCRSP
ExchangeNASDAQ

Contact

Therapeutic Areas

HemoglobinopathiesOncologyRegenerative MedicineCardiovascular DiseaseCentral Nervous System (CNS) DiseasesGenetic Diseases

Partners

Vertex PharmaceuticalsBayer AG
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