ChromaTan

ChromaTan

Pre-clinical
Philadelphia, United StatesFounded 2015chromatan.com

ChromaTan is revolutionizing downstream bioprocessing with its continuous, column-free chromatography platform designed to intensify purification and lower costs. The company's core technology, BioRMB™, utilizes a true moving bed of resin slurry within a disposable flowpath, offering significant advantages in resin utilization, operational simplicity, and product recovery for advanced modalities. Having raised bridge financing and won industry awards, ChromaTan is currently focused on deploying process development units, scaling revenue, and pursuing a Series B round to expand its market presence and application scope.

Market Cap
Private
Pipeline
Patents
Publications

Private Company

Total funding raised: $11.5M

AI Company Overview

ChromaTan is revolutionizing downstream bioprocessing with its continuous, column-free chromatography platform designed to intensify purification and lower costs. The company's core technology, BioRMB™, utilizes a true moving bed of resin slurry within a disposable flowpath, offering significant advantages in resin utilization, operational simplicity, and product recovery for advanced modalities. Having raised bridge financing and won industry awards, ChromaTan is currently focused on deploying process development units, scaling revenue, and pursuing a Series B round to expand its market presence and application scope.

Drug DeliveryBiologics

Technology Platform

The Kascade™ BioRMB™ platform is a patented, column-free, continuous chromatography system that uses a true moving bed of resin slurry for the intensified, low-pressure purification of biologics, offering dramatic reductions in resin use and operating costs.

Funding History

2
Total raised:$11.5M
Series A$10MNov 15, 2021
Seed$1.5MApr 15, 2019

Opportunities

The rapid growth of cell and gene therapies, which have acute purification challenges, presents a massive near-term opportunity.
The platform's resin and cost savings also offer a compelling value proposition for traditional biologics manufacturing, enabling facility footprint reduction and process intensification across the industry.

Risk Factors

Key risks include slow commercial adoption of a disruptive technology in a conservative industry, reliance on securing Series B funding to execute its scale-up plan, and potential technical challenges in scaling the system for large-volume cGMP manufacturing.
Competition from established chromatography vendors is also a significant threat.

Competitive Landscape

ChromaTan competes with traditional packed-bed chromatography vendors (Cytiva, Merck) and multi-column continuous systems (Cytiva, Novasep). Its primary differentiation is its true moving bed, column-free architecture, which offers simpler design, lower resin use, and gentler processing specifically advantageous for fragile gene therapy products.