Beam Therapeutics

Beam Therapeutics

BEAM
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BEAM · Stock Price

USD 31.47+14.06 (+80.76%)
Market Cap: $3.2B

Historical price data

Market Cap: $3.2BPipeline: 7 drugsPatents: 20Founded: 2017Employees: 251-500HQ: Cambridge, United States

Overview

Beam Therapeutics is a clinical-stage biotech leader in base editing, a next-generation gene editing technology designed for precise, single-base DNA corrections without double-strand breaks. The company's mission is to deliver durable, one-time cures for serious genetic diseases, with its lead program, BEAM-101 for sickle cell disease and beta-thalassemia, now in Phase 1/2 trials. Beam's strategy leverages a fully integrated platform spanning discovery, development, and in-house GMP manufacturing to build a broad pipeline and establish dominant intellectual property in the precision genetic medicine space.

HematologyImmunology & OncologyGenetic Liver Diseases

Technology Platform

Proprietary base editing platform enabling precise, single-letter DNA changes without creating double-strand breaks, utilizing cytosine and adenine base editors for correction, modulation, and multiplexed editing strategies.

Pipeline

7
7 drugs in pipeline
DrugIndicationStageWatch
BEAM-201Lymphoblastic LymphomaPhase 1/2
BEAM-101Sickle Cell DiseasePhase 1/2
BEAM-301: Single dose of BEAM-301 administered by IVGlycogen Storage Disease Type IaPhase 1/2
BEAM-302Alpha 1-Antitrypsin DeficiencyPhase 1/2
BEAM-103 + Placebo ComparatorHealthy SubjectsPhase 1

Funding History

3
Total raised:$402M
IPO$180M
Series B$135M
Series A$87M

Opportunities

Beam's base editing platform addresses a vast market of over 30,000 diseases linked to point mutations, with near-term multi-billion dollar opportunities in sickle cell disease, beta-thalassemia, and genetic liver disorders.
Successful clinical validation could establish a new therapeutic modality with best-in-class potential across multiple disease areas.

Risk Factors

Key risks include unproven long-term safety and efficacy of base editing in humans, potential for off-target effects, intense competition from other gene editing and therapeutic modalities, complex and costly manufacturing (especially for ex vivo therapies), and an evolving regulatory landscape for genetically modified products.

Competitive Landscape

Beam competes directly with CRISPR-Cas9 nuclease companies (e.g., CRISPR Therapeutics, Editas), other next-gen editing firms (e.g., Prime Medicine), and gene therapy/oligonucleotide developers. Its primary differentiation is the precision and safety profile of its non-cutting base editors, though it must continuously innovate to maintain its edge in a fast-moving field.

Company Timeline

2017Founded

Founded in Cambridge, United States

2018Series A

Series A: $87.0M

2019Series B

Series B: $135.0M

2020IPO

IPO — $180.0M