Beam Therapeutics

Beam Therapeutics

BEAMPhase 2

Beam Therapeutics is a clinical-stage biotechnology company developing a new class of precision genetic medicines based on its foundational base editing technology. The company's approach allows for the correction of point mutations, insertion or deletion of single bases, and modulation of gene expression with high efficiency and specificity. Beam is advancing a diversified pipeline of in vivo and ex vivo programs targeting sickle cell disease, alpha-1 antitrypsin deficiency, glycogen storage disease 1a, and various cancers. The company has established strategic collaborations with leading pharmaceutical partners and went public in February 2020.

Market Cap
$2.5B
Employees
400-500
Focus
Biotech

BEAM · Stock Price

USD 24.6333.40 (-57.56%)

Historical price data

AI Company Overview

Beam Therapeutics is a clinical-stage biotechnology company developing a new class of precision genetic medicines based on its foundational base editing technology. The company's approach allows for the correction of point mutations, insertion or deletion of single bases, and modulation of gene expression with high efficiency and specificity. Beam is advancing a diversified pipeline of in vivo and ex vivo programs targeting sickle cell disease, alpha-1 antitrypsin deficiency, glycogen storage disease 1a, and various cancers. The company has established strategic collaborations with leading pharmaceutical partners and went public in February 2020.

Technology Platform

Base editing technology enabling precise, programmable single-letter changes to DNA without creating double-strand breaks, allowing for correction of point mutations, gene modulation, and targeted knockouts with high specificity and efficiency.

Pipeline Snapshot

7

7 drugs in pipeline

DrugIndicationStage
BEAM-101Sickle Cell DiseasePhase 1/2
BEAM-301: Single dose of BEAM-301 administered by IVGlycogen Storage Disease Type IaPhase 1/2
BEAM-201Lymphoblastic LymphomaPhase 1/2
BEAM-302Alpha 1-Antitrypsin DeficiencyPhase 1/2
BEAM-103 + Placebo ComparatorHealthy SubjectsPhase 1

Funding History

3

Total raised: $402M

IPO$180MUndisclosedFeb 6, 2020
Series B$135MRedmile GroupMay 15, 2019
Series A$87MF-Prime CapitalMay 15, 2018

Opportunities

Beam has significant growth opportunities through advancing its clinical-stage programs in sickle cell disease and oncology, expanding its in vivo liver-directed therapies into the clinic, and leveraging its platform technology for new therapeutic applications.
Strategic partnerships with major pharmaceutical companies provide both validation and resources to pursue multiple disease areas simultaneously.

Risk Factors

Key risks include clinical development challenges inherent to novel gene editing therapies, intense competition from established gene editing companies, manufacturing complexities for cell and gene therapies, ongoing intellectual property disputes in the field, and potential market access hurdles due to high treatment costs.

Competitive Landscape

Beam faces competition from CRISPR Therapeutics/Vertex in ex vivo gene editing for hematological diseases, Intellia Therapeutics in in vivo CRISPR therapies, and several other gene editing companies. Beam differentiates through its base editing technology's precision advantages, broad pipeline spanning both in vivo and ex vivo approaches, and proprietary delivery capabilities.

Publications
18
Patents
20
Pipeline
7

Company Info

TypeTherapeutics
Founded2017
Employees400-500
LocationCambridge, United States
StagePhase 2
RevenuePre-revenue

Trading

TickerBEAM
ExchangeNASDAQ

Therapeutic Areas

HematologyOncologyGenetic DisordersMetabolic DiseasesLiver Diseases

Partners

PfizerApellis Pharmaceuticals
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