Apellis Pharmaceuticals
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Overview
Apellis Pharmaceuticals is on a mission to develop life-changing therapies by targeting C3, the central node of the complement cascade. The company has achieved a significant milestone with three regulatory approvals in four years, validating its platform and establishing commercial capabilities. Its strategy focuses on expanding the reach of its approved C3 inhibitor, pegcetacoplan, into new indications and geographies while advancing a pipeline of novel therapies for rare, retinal, and neurological diseases.
Technology Platform
Proprietary platform focused on targeted inhibition of the C3 protein, the central node of the complement cascade, to achieve comprehensive control over this part of the immune system across all activation pathways.
Pipeline
27| Drug | Indication | Stage | Watch |
|---|---|---|---|
| Pegcetacoplan | C3G | Phase 3 | |
| APL-2 + APL-2 | Geographic Atrophy | Phase 3 | |
| APL-2, Pegcetacoplan | Geographic Atrophy Secondary to Age-related Macular Degeneration | Phase 3 | |
| APL-2 | Paroxysmal Nocturnal Hemoglobinuria | Phase 3 | |
| Pegcetacoplan | Delayed Graft Function | Phase 3 |
FDA Approved Drugs
2Company Timeline
Founded in Boston, United States
FDA Approval: EMPAVELI
FDA Approval: SYFOVRE