AN2 Therapeutics

AN2 Therapeutics

ANTXPhase 3
Menlo Park, United Statesan2therapeutics.com

AN2 Therapeutics is focused on discovering and developing novel therapeutics derived from its boron chemistry platform, which enables the creation of selective inhibitors for challenging biological targets. The company has a pipeline of boron-based compounds in clinical and preclinical development for infectious diseases, including its lead candidate for Chagas disease. With experienced leadership from Anacor Pharmaceuticals and a commitment to global health, AN2 aims to deliver high-impact drugs to address critical unmet needs.

Market Cap
$143.8M

ANTX · Stock Price

USD 4.0011.40 (-74.03%)

Historical price data

AI Company Overview

AN2 Therapeutics is focused on discovering and developing novel therapeutics derived from its boron chemistry platform, which enables the creation of selective inhibitors for challenging biological targets. The company has a pipeline of boron-based compounds in clinical and preclinical development for infectious diseases, including its lead candidate for Chagas disease. With experienced leadership from Anacor Pharmaceuticals and a commitment to global health, AN2 aims to deliver high-impact drugs to address critical unmet needs.

Technology Platform

Boron-based drug discovery platform enabling creation of selective small molecule inhibitors through reversible covalent bonding, allowing targeting of biological pathways difficult to address with traditional carbon-based chemistry.

Pipeline Snapshot

6

6 drugs in pipeline, 1 in Phase 3

DrugIndicationStage
Epetraborole + PlaceboMAC Lung DiseasePhase 2/3
Epetraborole + Epetraborole + Placebo + PlaceboMycobacterium Abscessus InfectionPhase 2
EpetraboroleRenal InsufficiencyPhase 1
AN2-502998 + PlaceboHealthy VolunteersPhase 1
Epetraborole and matching placebo + Epetraborole + Placebo + MoxifloxacinHealthy VolunteersPhase 1

Opportunities

Significant unmet needs in neglected tropical diseases like Chagas disease and serious infections like melioidosis present substantial market opportunities.
The boron chemistry platform could be expanded to other therapeutic areas beyond infectious diseases, including oncology.
Partnerships with global health organizations could provide non-dilutive funding and accelerate development in high-need, low-resource settings.

Risk Factors

Clinical development risks are inherent for novel mechanisms in challenging infectious diseases.
Regulatory pathways for neglected tropical diseases can be complex across different geographies.
As a pre-revenue company, AN2 depends on capital markets for funding until potential commercialization.

Competitive Landscape

Limited direct competition in Chagas disease and melioidosis, where current treatments are suboptimal. Differentiation through boron chemistry allows targeting of pathways inaccessible to traditional antibiotics. The platform builds on proven success from Anacor Pharmaceuticals, providing validation for the approach.

Company Info

TypeTherapeutics
LocationMenlo Park, United States
StagePhase 3
RevenuePre-revenue

Trading

TickerANTX
ExchangeNASDAQ

Therapeutic Areas

Infectious DiseasesOncology

Partners

Bill and Melinda Gates Foundation (historical from leadership experience)Wellcome Trust (historical from leadership experience)Drugs for Neglected Disease initiative (DNDi) (historical from leadership experience)Medicines for Malaria Venture (historical from leadership experience)
SIMILAR COMPANIES
BASi Research Products
BASi Research Products
Pre-clinical · West Lafayette
Bay BioSciences
Bay BioSciences
Pre-clinical · San Francisco
EydisBio
EydisBio
Pre-clinical · Cambridge
3Spine
3Spine
Pre-clinical · Memphis
Belcher Pharmaceuticals
Belcher Pharmaceuticals
Pre-clinical · Miami
Is this your company?

Claim your profile to update information, add pipeline data, and connect with investors.

Claim profile