Allelica

Allelica is a US-based diagnostics company founded in 2015, focused on translating polygenic risk scores (PRS) into clinical practice. The company offers a dual business model: a direct-to-physician diagnostic service with tests like AbsoluteDx™ and Breast Risk Reveal™, and a bioinformatics software platform (Allelica Precision Server) for laboratories. Its core value proposition is providing validated, multi-ancestry PRS that integrate with existing clinical risk models to identify patients with elevated genetic risk missed by traditional tools like LDL-C or family history. Allelica is positioning itself at the forefront of the precision prevention movement, with its technology cited in emerging clinical guidelines.

Proprietary bioinformatics platform for developing and deploying multi-ancestry polygenic risk scores (PRS). The platform integrates genome-wide variant data, precise genetic ancestry analysis, and clinical risk models to provide comprehensive disease risk assessments. It is delivered via cloud-based and on-premise software (Allelica Precision Server) for labs and as cleared diagnostic tests (e.g., AbsoluteDx™, Breast Risk Reveal™) for clinicians.

Allelica competes with other dedicated PRS companies (e.g., Myriad Genetics' RiskScore), direct-to-consumer genomics firms expanding into health (e.g., 23andMe), and large diagnostic labs developing their own polygenic scores. Its key differentiators are its strong focus on multi-ancestry validation, integration with established clinical models, and flexible platform offering for laboratories.