Aanastra
There has been high level of recent interest in gene modulation with RNA based technologies (RNA translation, RNA interference, gene editing, etc). Delivery Systems for RNA (currently viral or lipid based) are essential because RNA can cause strong immune/cytokine responses and are highly susceptible to degradation. However, most delivery systems (e.g., lipid nanoparticles or viral-based systems) accumulate in the liver or result in immunogenicity after IV (systemic) administration, cause tox...
Private Company
Funding information not available
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There has been high level of recent interest in gene modulation with RNA based technologies (RNA translation, RNA interference, gene editing, etc). Delivery Systems for RNA (currently viral or lipid based) are essential because RNA can cause strong immune/cytokine responses and are highly susceptible to degradation. However, most delivery systems (e.g., lipid nanoparticles or viral-based systems) accumulate in the liver or result in immunogenicity after IV (systemic) administration, cause tox...