TSHA-101
GM2 Gangliosidosis (Tay-Sachs/Sandhoff)
PreclinicalPartnered (Astellas)
Key Facts
Indication
GM2 Gangliosidosis (Tay-Sachs/Sandhoff)
Phase
Preclinical
Status
Partnered (Astellas)
Company
About Taysha Gene Therapies
Taysha Gene Therapies is dedicated to eradicating monogenic CNS diseases through intrathecal delivery of gene therapies. The company has built a robust pipeline leveraging academic partnerships, most notably with UT Southwestern's Gene Therapy Program, and has advanced multiple candidates into clinical development. Following a strategic refocusing in 2023, Taysha is prioritizing its most promising assets, TSHA-102 for Rett syndrome and TSHA-120 for GAN, while seeking partnerships for earlier-stage programs. Its mission centers on addressing the high unmet need in rare neurological diseases with single-administration curative potential.
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